Creus M, Balasch J, Fábregues F, Martorell J, Boada M, Peñarrubia J, Barri P N, Vanrell J A
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Barcelona, Hospital Clínic i Provincial, Spain.
Hum Reprod. 1998 Jan;13(1):39-43. doi: 10.1093/humrep/13.1.39.
At present, it is well accepted that maternal recognition of paternally derived fetal antigens occurs during normal pregnancy and may be beneficial for implantation and maintenance of gestation. Thus, we have investigated the compatibility of human leukocyte antigens (HLA) in couples with successive failed in-vitro fertilization (IVF) cycles. Study group 1 included 50 couples with prior primary infertility who had not achieved a pregnancy after > or = 3 (range 3-7, mean 3.7) IVF cycles where at least two embryos (mean 3.3, range 2-4) were transferred in each attempt. An infertile control group (group 2) included 50 infertile couples undergoing IVF with the same indications as couples in group 1, who achieved a viable pregnancy with their first IVF attempt. The results were compared with those found in a population sample including 100 men and 100 women from the local population (group 3). We found a statistically significant (P < 0.05) excess of HLA sharing (> or = 2 antigens) between partners in group 1 as compared to groups 2. There was a trend toward increased HLA sharing in group 1 when groups 1 and 3 were compared. We conclude that some cases of implantation failure after IVF and embryo transfer might be caused by underlying close histocompatibility between partners.
目前，人们普遍认为，在正常妊娠期间母体可识别父源胎儿抗原，这可能有利于着床和维持妊娠。因此，我们研究了连续体外受精（IVF）周期失败的夫妇中人类白细胞抗原（HLA）的相容性。研究组1包括50对原发性不孕夫妇，他们在≥3次（范围3 - 7次，平均3.7次）IVF周期后仍未妊娠，每次尝试至少移植两个胚胎（平均3.3个，范围2 - 4个）。不育对照组（第2组）包括50对不育夫妇，他们因与第1组夫妇相同的指征接受IVF治疗，并在首次IVF尝试时成功妊娠。将结果与从当地人群中选取的100名男性和100名女性组成的群体样本（第3组）的结果进行比较。我们发现，与第2组相比，第1组夫妇之间HLA共享（≥2种抗原）的比例在统计学上有显著差异（P < 0.05）。当比较第1组和第3组时，第1组有HLA共享增加的趋势。我们得出结论，IVF和胚胎移植后某些着床失败的病例可能是由于夫妇之间潜在的紧密组织相容性所致。
