Simons F E, Schaller J G
Pediatrics. 1975 Jul;56(1):29-33.
Fifteen asymptomatic children with benign rheumatoid nodules, followed up to 12 years, are described. Nodules are characterized by subcutaneous location with predilection for pretibial regions and scalp, occasional large size, spontaneous regression, and frequent recurrence. Granuloma annulare was present in two patients. All 15 children were healthy and free from rheumatoid arthritis, rheumatic fever, or any other recognizable systemic disease at followup and none had positive tests for antinuclear antibodies or rheumatoid factors. Histologically the nodules closely resembled those seen in adult-onset rheumatoid arthritis. Though biopsy may be useful for confirmation of the clinical diagnosis of benign rheumatoid nodules, wide surgical excision, skin grafting, and treatment with medication are unnecessary in this self-limited syndrome.
本文描述了15例无症状的患有良性类风湿结节的儿童，随访时间长达12年。结节的特点是位于皮下，好发于胫前区和头皮，偶尔体积较大，可自发消退且经常复发。两名患者出现环状肉芽肿。随访时，所有15名儿童均健康，无类风湿关节炎、风湿热或任何其他可识别的全身性疾病，且抗核抗体或类风湿因子检测均为阴性。组织学上，这些结节与成人发病的类风湿关节炎中的结节非常相似。尽管活检可能有助于确诊良性类风湿结节的临床诊断，但对于这种自限性综合征，广泛的手术切除、植皮和药物治疗并无必要。
