时区：生物钟的比较遗传学

Time zones: a comparative genetics of circadian clocks.

作者信息

Young M W, Kay S A

机构信息

Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

出版信息

Nat Rev Genet. 2001 Sep;2(9):702-15. doi: 10.1038/35088576.

DOI:10.1038/35088576

PMID:11533719

Abstract

The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals. Intense genetic analysis during recent years has uncovered many of the components and molecular mechanisms comprising these clocks. Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms.

摘要

生物钟是一种广泛存在的细胞机制，是从细菌、真菌到植物和动物等生物体中各种节律功能的基础。近年来深入的遗传学分析揭示了构成这些生物钟的许多组成部分和分子机制。尽管自动调节遗传网络是所有生物钟设计中的一个一致特征，但证据表明它们在不同王国中具有独立的进化起源。