Al-Awamy B H
Department of Pediatrics, King Faisal University, PO Box 5438, Dammam 31422, Kingdom of Saudi Arabia.
Saudi Med J. 2000 Jan;21(1):8-17.
The geographical distribution of Alpha and Beta-Thalassemias differ markedly. Alpha-Thalassemia being particularly prevalent in Southeast Asia and Beta-Thalassemia in the Mediterranean basin. Thalassemia syndromes are common in Saudi Arabia: the Beta-Thalassemia genes occur with variable frequency in different regions of Saudi Arabia and both B+ and Bo thalassemia have been reported. Alpha-Thalassemia is also highly prevalent here and the interaction with the sickle cell gene is commonly observed. Over the last few years, a great deal of information regarding the clinical, molecular and management of these disorders has accumulated in the literature. In this paper we summarize some of the recent studies on the subject along with our experience and our attempt to highlight a number of questions still awaiting answers.
α地中海贫血和β地中海贫血的地理分布差异显著。α地中海贫血在东南亚尤为普遍，而β地中海贫血在地中海盆地较为常见。地中海贫血综合征在沙特阿拉伯很常见：β地中海贫血基因在沙特阿拉伯不同地区的出现频率各不相同，并且已报道了B+和β0地中海贫血。α地中海贫血在这里也非常普遍，并且经常观察到与镰状细胞基因的相互作用。在过去几年中，文献中积累了大量关于这些疾病的临床、分子和治疗方面的信息。在本文中，我们总结了一些关于该主题的最新研究以及我们的经验，并试图突出一些仍有待解答的问题。
