Macías-Tomei Coromoto, López-Blanco Mercedes, Espinoza Isbelia, Vasquez-Ramirez Maura
Departamento de Auxología, División de Investigaciones Biológicas, Fundacredesa, Caracas, Venezuela.
Am J Hum Biol. 2000 Jan;12(1):88-96. doi: 10.1002/(SICI)1520-6300(200001/02)12:1<88::AID-AJHB10>3.0.CO;2-H.
Changes between pubertal stages (PS) are best analyzed in a longitudinal context. A sample of 67 boys and 48 girls from the Caracas Longitudinal Study who presented data for the full range of pubertal development: genitalia (G2-G5), breast (B2-B5), pubic hair (PH2-PH5), axillary hair (AH2-AH3), and age at menarche (AM) during follow-up, were assessed at clinical examination. Medians and standard errors for ages at each stage were estimated with the logit method. For length of intervals between stages of genitalia, breast, pubic hair and axillary hair, intervals B2-M and PH2-M, survival analysis was used according to life tables and Cox regression analysis. In boys, G2 occurred at 11.61 years; in girls, B2 occurred at 10.35 years and AM at 12.55 years of age. In both sexes, length of the intervals PS 2-3 and 3-4 were approximately 1 year, while PS 4-5 was 1.5 years. Duration of puberty reached 3.7 years in boys (G2-G5) and 3.3 years in girls (B2-B5); corresponding intervals for PH2-PH5 were 3.1 and 3.0 years in boys and girls, respectively. B2-AM was 1.8 years (with a range of 0.3-3.6 years) and PH2-AM was 1.5 years (with a range 0.3-3.5 years). These results are useful for screening and monitoring: identifying abnormal pubertal patterns in subjects who are advanced or delayed with respect to their peers, together with other pubertal events such as age at peak height and weight velocity and skeletal age. Am. J. Hum. Biol. 12:88-96, 2000. Copyright 2000 Wiley-Liss, Inc.
青春期阶段（PS）之间的变化最好在纵向背景下进行分析。来自加拉加斯纵向研究的67名男孩和48名女孩的样本，他们提供了青春期发育全阶段的数据：生殖器（G2 - G5）、乳房（B2 - B5）、阴毛（PH2 - PH5）、腋毛（AH2 - AH3）以及随访期间的初潮年龄（AM），在临床检查时进行了评估。使用logit方法估计每个阶段年龄的中位数和标准误差。对于生殖器、乳房、阴毛和腋毛各阶段之间的间隔时长，以及B2 - M和PH2 - M间隔，根据生命表和Cox回归分析使用生存分析。在男孩中，G2出现在11.61岁；在女孩中，B2出现在10.35岁，AM出现在12.55岁。在两性中，PS 2 - 3和3 - 4阶段的间隔时长约为1年，而PS 4 - 5为1.5年。男孩青春期持续时间为3.7年（G2 - G5），女孩为3.3年（B2 - B5）；男孩和女孩PH2 - PH5的相应间隔分别为3.1年和3.0年。B2 - AM为1.8年（范围为0.3 - 3.6年），PH2 - AM为1.5年（范围为0.3 - 3.5年）。这些结果对于筛查和监测很有用：识别相对于同龄人提前或延迟的受试者的异常青春期模式，以及其他青春期事件，如身高和体重增长速度峰值年龄和骨龄。《美国人类生物学杂志》12:88 - 96，2000年。版权所有2000年威利 - 利斯公司。
