Largo R H, Prader A
Helv Paediatr Acta. 1983 Aug;38(3):211-28.
Pubertal development between 8 and 18 years is reported in 142 Swiss males of the First Zurich Longitudinal Study (1954-1980). Genital and pubic hair development were rated according to TANNER [14]. Testicular growth was assessed by comparative palpation with the orchiometer of PRADER [10]. The age at which pubertal development was initiated varied between the eighth and the fifteenth year of life. Reaching a testicular volume of 3 ml was found to be the most reliable indicator for the onset of pubertal development. The various pubertal stages of genital and pubic hair development tended to occur at earlier ages in this study than previously reported. This was particularly true for PH6 which was observed in 73% of the boys by age 20. Standard deviations of 1.0 to 1.5 years for the ages at which the pubertal stages were reached reflected the large variations in the timing of pubertal development. The mean duration of genital development was 3.5 +/- 1.1 years, of pubertal penis growth 1.8 +/- 0.7 years, of pubertal testicular growth 3.5 +/- 1.0 years and of pubic hair development 2.7 +/- 1.0 years. Moderate correlations were found between the ages at which genital development, pubic hair development and pubertal testicular growth were initiated. The ages at completion of these pubertal characters and the age at which the peak of the adolescent growth spurt was reached were highly positively correlated with each other. For a given stage of a pubertal character at least 80% of the children were within two successive stages of any other pubertal character, e.g. 87% of the boys were either in G2 or G3 when they reached PH2. No significant relationship between the durations of genital development, pubic hair development and pubertal testicular growth could be established. Likewise no significant relationship could be found between the timing and duration of pubertal development.
在苏黎世第一纵向研究(1954 - 1980年)的142名瑞士男性中报告了8至18岁的青春期发育情况。生殖器和阴毛发育根据坦纳[14]进行分级。睾丸生长通过与普拉德睾丸测量器[10]进行比较触诊来评估。青春期发育开始的年龄在8岁至15岁之间变化。发现睾丸体积达到3毫升是青春期发育开始的最可靠指标。在本研究中,生殖器和阴毛发育的各个青春期阶段往往比以前报告的年龄更早出现。对于阴毛发育6期(PH6)尤其如此,到20岁时,73%的男孩出现了该阶段。达到青春期各阶段的年龄标准差为1.0至1.5年,这反映了青春期发育时间的巨大差异。生殖器发育的平均持续时间为3.5±1.1年,青春期阴茎生长为1.8±0.7年,青春期睾丸生长为3.5±1.0年,阴毛发育为2.7±1.0年。在生殖器发育、阴毛发育和青春期睾丸生长开始的年龄之间发现了中等程度的相关性。这些青春期特征完成的年龄与青春期生长突增高峰达到的年龄高度正相关。对于青春期某一特征的给定阶段,至少80%的儿童处于任何其他青春期特征的两个连续阶段内,例如,87%的男孩在达到阴毛发育2期(PH2)时处于生殖器发育2期(G2)或3期(G3)。在生殖器发育、阴毛发育和青春期睾丸生长的持续时间之间无法建立显著关系。同样,在青春期发育的时间和持续时间之间也未发现显著关系。