[Ultrastructural characteristics of reactive changes in the epithelium of the kidney proximal tubules in massive proteinuria in children].

The investigation was designed to analyse the mechanism of the protein transport on the basis of the estimation of ultrastructural organization of the epithelium of proximal convoluted tubules of kidneys of the children, suffering from the nephritic form of glomerulonephritis for a long time. It was established that high tubular proteinuria (from 0.33 to 6.6 g/l) causes many changes in apical, central and basal parts of epithelial cells as well as in intercellular spaces. It was stated that massive proteinuria provoked adaptive processes in epithelial cells of proximal tubules. At the same time signs of exhaustion of adaptive capacities of proximal nephrocytes were demonstrated.