加速动脉粥样硬化、抗磷脂抗体与抗磷脂综合征。

Accelerated atheroma, antiphospholipid antibodies, and the antiphospholipid syndrome.

作者信息

George J, Haratz D, Shoenfeld Y

机构信息

Department of Cardiology, Tel Aviv Medical Center, Tel Aviv, Israel.

出版信息

Rheum Dis Clin North Am. 2001 Aug;27(3):603-10, vii. doi: 10.1016/s0889-857x(05)70223-4.

DOI:10.1016/s0889-857x(05)70223-4

PMID:11534263

Abstract

Indirect data coming from animal studies and in vitro observations support the contention that the mere presence of antiphospholipid antibodies may be sufficient to increase atheroma development, regardless of other predisposing factors. It seems that humoral and cellular immune responses to beta 2-glycoprotein I can play an important role in mediating the increased propensity to atherosclerosis.

摘要

来自动物研究和体外观察的间接数据支持了这样一种观点，即仅抗磷脂抗体的存在可能就足以促进动脉粥样硬化的发展，而与其他易感因素无关。对β2糖蛋白I的体液免疫和细胞免疫反应似乎在介导动脉粥样硬化易感性增加方面发挥重要作用。