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Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis.

作者信息

Adler Arnon, Afek Arnon, Levy Yair, Keren Gad, George Jacob

机构信息

Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

出版信息

Nat Clin Pract Cardiovasc Med. 2009 Mar;6(3):215-8. doi: 10.1038/ncpcardio1436. Epub 2009 Jan 13.

DOI:10.1038/ncpcardio1436
PMID:19139745
Abstract

BACKGROUND

A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina.

INVESTIGATIONS

Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG.

DIAGNOSIS

Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel.

MANAGEMENT

The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.

摘要

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