Neuhaus J, Dorschner W, Mondry J, Stolzenburg J U
Department of Urology, University of Leipzig, Stephanstrasse 11, D-04103 Leipzig.
Anat Histol Embryol. 2001 Aug;30(4):185-92. doi: 10.1046/j.1439-0264.2001.00323.x.
The guinea-pig is often used for experimental studies in urology. However, the anatomy of the lower urinary tract of the guinea-pig is poorly described in the literature. The structure and function of the lower urinary tract, i.e. continence, micturition and sexual function, are closely related to the gross anatomy of the pelvis and the fine structure of the musculature. We investigated the anatomy and histomorphology of the lower urinary tract by serial sections in male guinea-pigs and compared it to that in humans. Immunohistochemical stainings for alpha-smooth muscle cell actin were used to differentiate between smooth and striated muscles. By using whole pelvic preparations, including all internal organs preserved in their in situ location for three-dimensional reconstruction, we developed three-dimensional models, which elucidate the spatial relationship of all muscular structures and can help to deduce functional aspects of lower urinary tract function. In the guinea-pig, most of the muscles found in humans can be demonstrated in comparable location and extension. However, the structure of the prostate and the existence of the so-called coagulation glands define a significant difference in the morphology of the prostatic urethra.
豚鼠常用于泌尿外科的实验研究。然而，文献中对豚鼠下尿路的解剖描述较少。下尿路的结构和功能，即控尿、排尿和性功能，与骨盆的大体解剖结构和肌肉组织的精细结构密切相关。我们通过对雄性豚鼠进行连续切片研究了下尿路的解剖结构和组织形态，并将其与人类的进行了比较。使用α-平滑肌肌动蛋白的免疫组织化学染色来区分平滑肌和横纹肌。通过使用包括所有原位保存的内部器官的全盆腔标本进行三维重建，我们构建了三维模型，该模型阐明了所有肌肉结构的空间关系，并有助于推断下尿路功能的功能方面。在豚鼠中，人类中发现的大多数肌肉在可比的位置和范围都能找到。然而，前列腺的结构和所谓凝固腺的存在定义了前列腺尿道形态的显著差异。
