Balfour D J, Morrison C F
Pharmacol Biochem Behav. 1975 May-Jun;3(3):349-54. doi: 10.1016/0091-3057(75)90042-8.
Rats were trained on a Sidman lever-pressing avoidance task. Half the animals received 0.4 mg nicotine/kg before each avoidance session. Rats which were successful performers had heavier adrenal glands. Nicotine facillitated avoidance and increased adrenal weight. Successful avoiders also tended to have higher hippocampal 5-HT levels. Hypothalamic 5-HT was elevated in animals which had just received many shocks during the final avoidance session but not in rats which had received a comparable number of unavoidable shocks. No effects of nicotine on noradrenaline or corticosterone were detected nor were these measures related to avoidance performance.
大鼠接受西德曼杠杆按压回避任务训练。一半动物在每次回避训练前接受0.4毫克尼古丁/千克的剂量。成功完成任务的大鼠肾上腺更重。尼古丁促进回避行为并增加肾上腺重量。成功的回避者海马5-羟色胺水平也往往更高。在最后一次回避训练中刚受到多次电击的动物下丘脑5-羟色胺水平升高，但在受到相同数量不可避免电击的大鼠中则未升高。未检测到尼古丁对去甲肾上腺素或皮质酮有影响，这些指标也与回避表现无关。
