Hochól A, de Caro R, Jedrzejczak N, Markowska A, Trejter M, Nussdorfer G G, Malendowicz L K
Department of Histology and Embryology, School of Medicine, Poznan, Poland.
Cytobios. 2001;106 Suppl 1:119-24.
The effects of three subcutaneous injections of 3 nmol/100 g body weight of the cholecystokinin type 2 (CCK2) receptor agonist pentagastrin on adrenocorticotrophic hormone (ACTH) and corticosterone secretion and proliferative activity of regenerating rat adrenal cortex were investigated. Pentagastrin did not alter either ACTH and corticosterone plasma concentrations or the adrenal mitotic index at day 5 of regeneration. In contrast, it increased (by about 50%) the adrenal mitotic index at day 8 of regeneration, and the effect was blocked by the simultaneous administration of equimolar doses of the CCK2-receptor antagonist PD-135,158. It is suggested that the activation of CCK2 receptors exerts a growth promoting action on the regenerating rat adrenal cortex.
研究了皮下注射三次、剂量为3纳摩尔/100克体重的胆囊收缩素2型（CCK2）受体激动剂五肽胃泌素对再生大鼠肾上腺皮质促肾上腺皮质激素（ACTH）和皮质酮分泌以及增殖活性的影响。五肽胃泌素在再生第5天时既未改变ACTH和皮质酮的血浆浓度，也未改变肾上腺有丝分裂指数。相反，在再生第8天时，它使肾上腺有丝分裂指数增加了（约50%），并且该作用被同时给予等摩尔剂量的CCK2受体拮抗剂PD-135,158所阻断。提示CCK2受体的激活对再生大鼠肾上腺皮质具有促生长作用。
