用于片剂制造直接压片的一些材料作为干黏合剂的研究。第2部分：比较自黏合性能。
Investigation of some materials as dry binders for direct compression in tablet manufacture. Part 2: Comparative self-binding properties.
作者信息
Asker A F, Saied K M, Abdel-Khalek M M
出版信息
Pharmazie. 1975 Apr;30(4):236-8.
PMID:1153489
Abstract
Comparative self-binding qualities of four substances studied as potential dry binders for direct compression applications in tablet making were investigated. The effect of particle size of these materials on hardness, friability and hardness-friability ratio of disks made with mere binders was studied. The results showed that for comparable particle sizes, values of hardness-friability ratio of the various disks were in the following descending order: Plasdone, tragacanth, Carbowax 4000 and then mannitol.
摘要
研究了四种作为直接压片用潜在干黏合剂的物质的比较自黏合特性。研究了这些材料的粒度对仅用黏合剂制成的圆片的硬度、脆碎度和硬度 - 脆碎度比的影响。结果表明，对于可比的粒度，各种圆片的硬度 - 脆碎度比的值按以下降序排列：聚维酮、刺梧桐树胶、聚乙二醇4000，然后是甘露醇。
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