Tang O S, Thong K J, Baird D T
Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, Scotland, UK.
Contraception. 2001 Jul;64(1):29-32. doi: 10.1016/s0010-7824(01)00219-0.
The treatment outcomes of 956 women undergoing second trimester termination of pregnancy with mifepristone and gemeprost were studied. The median gestational age was 16 weeks (range: 12-24 weeks). All women were treated with 200 mg mifepristone orally, followed 36 h later with 1 mg vaginal gemeprost administered every 6 h to a maximum of 4 doses in the first 24 h. A second course of 1 mg vaginal gemeprost was given 3-hourly in the next 12 h, if abortion had not occurred. Overall, 96.4% and 98.8% of the women aborted within 24 and 36 h, respectively. The median induction-to-abortion interval was 7.8 h (range: 0.5-109.9 h). The induction-abortion interval was longer in nulliparous women and women with a gestation age 17 weeks or above. Surgical evacuation of the uterus was performed in 11.5% of women for incomplete abortion or retained placenta. More multiparous women (16.7%) required surgical evacuation of uterus than did nulliparous women (7.3%; p <0.001). Ten (0.1%) women failed to abort with gemeprost and required other methods for abortion. In conclusion, a combination of mifepristone and gemeprost is a safe, effective, and noninvasive method of medical abortion for second trimester pregnancy.
对956名使用米非司酮和吉美前列素进行中期妊娠终止的女性的治疗结果进行了研究。中位妊娠周数为16周（范围：12 - 24周）。所有女性均口服200 mg米非司酮，36小时后每6小时阴道给予1 mg吉美前列素，在前24小时内最多给予4剂。如果流产未发生，在接下来的12小时内每3小时给予第二疗程的1 mg阴道吉美前列素。总体而言，分别有96.4%和98.8%的女性在24小时和36小时内流产。中位引产至流产间隔时间为7.8小时（范围：0.5 - 109.9小时）。初产妇和妊娠周数在17周及以上的女性引产至流产间隔时间更长。11.5%的女性因流产不全或胎盘残留而进行了子宫手术清宫。经产妇（16.7%）比初产妇（7.3%）更需要进行子宫手术清宫（p<0.001）。10名（0.1%）女性使用吉美前列素流产失败，需要采用其他流产方法。总之，米非司酮和吉美前列素联合使用是一种安全、有效且无创的中期妊娠药物流产方法。
