Kacprzak-Bergman I, Zaleska I, Jasonek J
Department of Pediatric Infectious Diseases, Medical University, Wroclaw, Poland.
Med Sci Monit. 2001 Sep-Oct;7(5):977-81.
The pathogenesis of mumps meningitis remains unclear. The aim of this study was to assess the relation between IgM and IgG levels in blood and their relationship with the picture of CSF.
We tested 40 children of both sexes aged 2-14 years. CSF was examined at admission (I) and after 12-14 days (II). Antibodies were measured four times: at admission (I), and after 2 (II), 4 (III), and 8 weeks (IV) by EIA (Behring). The results were expressed as delta absorbency.
The mean IgM level was respectively 0.403; 0.424; 0.317; 0.220. Significant differences were demonstrated between tests I and III and between III and IV. The mean IgG level was respectively 0.923; 1.322; 1.381 and 1.257. Significant differences were noted between tests I and II and between III and IV. We observed significant positive correlations between the IgM levels in tests I and II, II and III, and III and IV. The IgG concentrations significantly correlated in tests I and II, II and III, and II and IV. Significant negative correlations were noted between the IgG levels at test I and the IgM levels at test II. A negative correlation also appeared between the IgM level and CFS pleocytosis at admission, and between the IgM concentration and CSF pleocytosis after two weeks. A positive correlation was found between the IgG level at test I and the CSF glucose level in test II. In this study a high IgG level probably resulted in a lower IgM level at the next test. The IgM concentration at week 8 weeks was about 50% lower than its highest concentration (week 2), while the IgG level decreased simultaneously. The IgM concentration at hospital admission and two weeks later influenced CSF pleocytosis during these periods (higher IgM level - lower pleocytosis). A high IgG level at admission resulted in a lower CSF glucose concentration at the second examination.
腮腺炎脑膜炎的发病机制仍不清楚。本研究的目的是评估血液中IgM和IgG水平之间的关系及其与脑脊液情况的关系。
我们对40名年龄在2至14岁的男女儿童进行了检测。在入院时（I）和12 - 14天后（II）对脑脊液进行检查。通过酶免疫分析（贝林公司）在四个时间点检测抗体：入院时（I）、2周后（II）、4周后（III）和8周后（IV）。结果以吸光度差值表示。
IgM平均水平分别为0.403；0.424；0.317；0.220。在检测I和III之间以及III和IV之间显示出显著差异。IgG平均水平分别为0.923；1.322；1.381和1.257。在检测I和II之间以及III和IV之间观察到显著差异。我们观察到检测I和II、II和III以及III和IV之间的IgM水平存在显著正相关。IgG浓度在检测I和II、II和III以及II和IV之间显著相关。在检测I时的IgG水平与检测II时的IgM水平之间存在显著负相关。入院时IgM水平与脑脊液细胞数增多之间以及两周后IgM浓度与脑脊液细胞数增多之间也出现负相关。在检测I时的IgG水平与检测II时的脑脊液葡萄糖水平之间发现正相关。在本研究中，高IgG水平可能导致下一次检测时IgM水平降低。8周时的IgM浓度比其最高浓度（2周时）低约50%，而IgG水平同时下降。入院时和两周后的IgM浓度影响了这些时期的脑脊液细胞数增多情况（IgM水平越高 - 细胞数增多越少）。入院时高IgG水平导致第二次检查时脑脊液葡萄糖浓度降低。
