Bastomsky C H, Wyse J M
Res Commun Chem Pathol Pharmacol. 1975 Apr;10(4):725-33.
Microscope immersion oil, applied to the skin of rats or injected intraperitoneally, led to a substantial increase in the biliary excretion of intravenously injected 125-I-thyroxine (T4), elevated the bile: plasma 125-I ratio, enhanced the biliary clearance rate of plasma 125-I-T-4 and increased the proportion of biliary 125-I present as T-4-glucuronide. Immersion oil applied to the skin was at least as effective as injected intraperitoneally. Skin application also elevated bile flow, liver weight, thyroid 131-I uptake and Sephadex uptake of serum 125-I-triiodothyronine (indicating reduced binding of thyroid hormone to serum proteins) and depressed serum T-4 concentrations. These effects were similar to those previously observed after intraperitoneal injection of a polychlorinated biphenyl mixture.
将显微镜浸油涂抹在大鼠皮肤上或腹腔注射后，会使静脉注射的125-I-甲状腺素（T4）的胆汁排泄量大幅增加，提高胆汁与血浆的125-I比率，增强血浆125-I-T4的胆汁清除率，并增加以T-4-葡萄糖醛酸苷形式存在的胆汁125-I的比例。涂抹在皮肤上的浸油效果至少与腹腔注射相当。皮肤涂抹还会提高胆汁流量、肝脏重量、甲状腺对131-I的摄取以及血清125-I-三碘甲状腺原氨酸的葡聚糖摄取（表明甲状腺激素与血清蛋白的结合减少），并降低血清T-4浓度。这些效应与先前腹腔注射多氯联苯混合物后观察到的效应相似。
