Gaginella T S, Vallner J J
Res Commun Chem Pathol Pharmacol. 1975 Jun;11(2):323-6.
Indomethacin was vulcanized in dimethylpolysiloxane, an inert silicone suitable for tissue implantation. The drug is released from this polymer matrix gradually in amounts that can inhibit endogenous prostaglandin synthesis. The method is simple, rapid and inexpensive and eliminates repetitive administration in studies where prolonged inhibition of prostaglandin synthesis is desired.
吲哚美辛被硫化于二甲基聚硅氧烷中，二甲基聚硅氧烷是一种适用于组织植入的惰性硅酮。药物从该聚合物基质中逐渐释放，其释放量能够抑制内源性前列腺素的合成。该方法简单、快速且成本低廉，并且在期望长期抑制前列腺素合成的研究中无需重复给药。
