Ueno N, Refojo M F, Liu L H
J Biomed Mater Res. 1982 Sep;16(5):669-77. doi: 10.1002/jbm.820160514.
The release rates of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), an anticancer drug, from various kinds of silicone and silicone-nylon implantable and refillable devices were investigated in vitro. The devices were made with different surface areas and wall thicknesses. The relation of the release rate at steady state to the surface area and the relation of the release rate per unit surface area to the wall thickness were determined. The relationship among the release rate, the surface area, and the wall thickness was analyzed using the multiple regression method, and is represented on a three-dimensional graph. The multiple regression equation predicts the release rate from the surface area and the wall thickness; the release rate can also be read from a nomogram that is presented.
对1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀，一种抗癌药物）从各种硅酮和硅酮-尼龙可植入及可再填充装置中的体外释放速率进行了研究。这些装置具有不同的表面积和壁厚。确定了稳态释放速率与表面积的关系以及单位表面积释放速率与壁厚的关系。使用多元回归方法分析了释放速率、表面积和壁厚之间的关系，并在三维图上表示出来。多元回归方程可根据表面积和壁厚预测释放速率；释放速率也可从所给出的列线图中读取。
