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小鼠体内大麻酚的转化

Transformations of cannabinol in the mouse.

作者信息

Burstein S, Varanelli C

出版信息

Res Commun Chem Pathol Pharmacol. 1975 Jul;11(3):343-54.

PMID:1153880
Abstract

The in vivo transformations of cannabinol (CBN) in the mouse have been studied and a pattern of metabolism established. As with other cannabinoids, the 7 position and the side chain are hydroxylated followed by further oxidation to acidic metabolites. Two of these CBN metabolites have been isolated previously as metabolites of delta1-tetrahydrocannabinol (THC) suggesting that CBN may be a transformation product of delta1-THC.

摘要

已对小鼠体内大麻酚(CBN)的转化进行了研究,并建立了代谢模式。与其他大麻素一样,7位和侧链会发生羟基化,随后进一步氧化为酸性代谢物。这些CBN代谢物中的两种先前已作为δ1-四氢大麻酚(THC)的代谢物分离出来,这表明CBN可能是δ1-THC的转化产物。

相似文献

1
Transformations of cannabinol in the mouse.小鼠体内大麻酚的转化
Res Commun Chem Pathol Pharmacol. 1975 Jul;11(3):343-54.
2
Identification of glucuronides as in vivo liver conjugates of seven cannabinoids and some of their hydroxy and acid metabolites.鉴定葡糖醛酸苷为七种大麻素及其一些羟基和酸代谢物在体内的肝脏共轭物。
Res Commun Chem Pathol Pharmacol. 1977 Feb;16(2):265-79.
3
Further studies on the oxidative cleavage of the pentyl side-chain of cannabinoids: identification of new biotransformation pathways in the metabolism of 3'-hydroxy-delta-9-tetrahydrocannabinol by the mouse.大麻素戊基侧链氧化裂解的进一步研究:小鼠对3'-羟基-δ-9-四氢大麻酚代谢中新生物转化途径的鉴定
Xenobiotica. 1989 Dec;19(12):1437-47. doi: 10.3109/00498258909043194.
4
Studies on the beta-oxidative metabolism of delta 1- and delta 6-tetrahydrocannabinol in the mouse. The in vivo biotransformation of metabolites oxidized in the side chain.小鼠体内δ1-和δ6-四氢大麻酚的β-氧化代谢研究。侧链氧化代谢产物的体内生物转化。
Drug Metab Dispos. 1985 Mar-Apr;13(2):215-9.
5
In vivo metabolism of (+)-trans-delta-9-tetrahydrocannabinol in the mouse.小鼠体内(+)-反式-δ-9-四氢大麻酚的代谢
Biomed Environ Mass Spectrom. 1988 Jan 15;15(2):117-22. doi: 10.1002/bms.1200150210.
6
Chemical synthesis and biological occurrence of carboxylic acid metabolites of delta1(6)-tetrahydrocannabinol.
Drug Metab Dispos. 1979 May-Jun;7(3):155-61.
7
Identification of six substituted 4''-hydroxy-metabolites of of delta1-tetrahydrocannabinol in mouse liver.
Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):435-46.
8
In vivo metabolism of the ethyl homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouse.小鼠体内δ-8-四氢大麻酚和δ-9-四氢大麻酚的乙基同系物的代谢
Biol Mass Spectrom. 1991 May;20(5):324-8. doi: 10.1002/bms.1200200514.
9
Oxidative cleavage of the pentyl side-chain of cannabinoids. Identification of new biotransformation pathways in the metabolism of 4'-hydroxy-delta-9-tetrahydrocannabinol in the mouse.大麻素戊基侧链的氧化裂解。小鼠体内4'-羟基-δ-9-四氢大麻酚代谢中新生物转化途径的鉴定。
Drug Metab Dispos. 1990 May-Jun;18(3):350-5.
10
In vivo metabolism of the n-butyl-homologues of delta 9-tetrahydrocannabinol and delta 8-tetrahydrocannabinol by the mouse.小鼠对δ9-四氢大麻酚和δ8-四氢大麻酚正丁基同系物的体内代谢
Xenobiotica. 1988 Apr;18(4):417-27. doi: 10.3109/00498258809041678.

引用本文的文献

1
Microbiological oxidation of the pentyl side chain of cannabinoids.大麻素戊基侧链的微生物氧化
Experientia. 1978 Aug 15;34(8):1020-2. doi: 10.1007/BF01915321.