Transformations of cannabinol in the mouse.

The in vivo transformations of cannabinol (CBN) in the mouse have been studied and a pattern of metabolism established. As with other cannabinoids, the 7 position and the side chain are hydroxylated followed by further oxidation to acidic metabolites. Two of these CBN metabolites have been isolated previously as metabolites of delta1-tetrahydrocannabinol (THC) suggesting that CBN may be a transformation product of delta1-THC.