Gershbein L L
Res Commun Chem Pathol Pharmacol. 1975 Jul;11(3):445-66.
The effect of aromatic hydrocarbons and derivatives and heterocyclic agents administered s.c. daily for the first 7 days or as dietary supplements was ascertained on the extent of liver regeneration in partially hepatectomized male rats over a period of 10 days. The monoalkylbenzenes proved ineffective by injection except for ethylbenzene and possibly n-propylbenzene and the introduction of the double or triple bond in the side-chain as exemplified by styrene and phenylacetylene, led to little change over the respective controls. A number of noncarcinogenic hydrocarbons accelerated the regenerative process but much higher s.c. dosages were required as compared to the carcinogenic hydrocarbons. As tested by the dietary route, the optimum effect among the phenylmethanes was reached with diphenylmethane, toluene, tri- and tetraphenylmethanes and the Sn analog, tin tetraphenyl being inactive. With the diets, carcinogens as BP or DBA at 0.10% were without effect whereas acenaphthene or fluoranthene at this level accelerated the regeneration. Although diets supplemented with anthracene or octahydroanthracene led to little change in liver increment, 9,10-dihydroanthracene, anthraquinone and anthrone comprised liver stimulants, an activity which did not extend to phenanthraquinone. Aniline and triphenylamine did not alter the control increment but diphenylamine was active as was also the case with o- and m-terphenyls, the p-isomer being ineffective. Although naphthalene lacked activity by either route, 1- and 2-phenylnaphthalenes proved stimulatory by injection and 1- and 2-naphthylamines, by diet. Among other derivatives, phenyl sulfide and its sulfoxide and sulfone were quite stimulatory in addition to heterocyclic S compound as benzothiophene, phenothiazine, phenoxathiin and thianthrene but not thianaphthene at the dietary levels screened. Several series were conducted with intact rats under the above conditions; ethyl-benzene and phenathrene injected s.c. at high levels did not alter the control dry- or wet liver-body weight ratios. The findings are summarized in Table 4.
研究了在部分肝切除的雄性大鼠中，于最初7天每天皮下注射芳香烃及其衍生物和杂环化合物或作为膳食补充剂时，对其肝脏再生程度在10天内的影响。除乙苯以及可能的正丙苯外，单烷基苯经注射证明无效，并且侧链中引入双键或三键（如苯乙烯和苯乙炔所示），与各自的对照组相比变化不大。一些非致癌性烃加速了再生过程，但与致癌性烃相比，需要更高的皮下注射剂量。通过膳食途径测试，二苯甲烷、甲苯、三苯甲烷和四苯甲烷以及锡的类似物四苯基锡（无活性）中，二苯甲烷达到了苯甲烷类中的最佳效果。对于膳食而言，0.10%的致癌物如BP或DBA没有效果，而在此水平的苊或荧蒽加速了再生。尽管补充蒽或八氢蒽的膳食导致肝脏增量变化不大，但9,10 - 二氢蒽、蒽醌和蒽酮是肝脏刺激剂，这种活性并不延伸至菲醌。苯胺和三苯胺没有改变对照增量，但二苯胺有活性，邻三联苯和间三联苯也是如此，对三联苯的对映异构体无活性。尽管萘通过任何一种途径都缺乏活性，但1 - 和2 - 苯基萘经注射证明有刺激作用，1 - 和2 - 萘胺经膳食证明有刺激作用。在其他衍生物中，除了杂环硫化合物如苯并噻吩、吩噻嗪、吩恶噻嗪和噻蒽外，苯硫醚及其亚砜和砜在筛选的膳食水平下也具有相当的刺激作用，但噻吩无此作用。在上述条件下，用完整大鼠进行了几个系列的实验；皮下注射高剂量的乙苯和菲没有改变对照的肝脏干重或湿重与体重的比值。研究结果总结在表4中。
