Gershbein L L
Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):139-45.
The extent of liver regeneration in partially hepatectomized rats was increased over a period of 10 days on feeding a basal diet supplemented with 1,1'-diacetylferrocene at 0.15% by weight but the respective differences over the controls were not significant with diets containing ferrocene (0.10 and 0.30%) and acetylferrocene (0.10%) or on sc injection of these agents in peanut oil solution. Tropolone and colchicine supplemented at 750 and 100 PPM, respectively, depressed the regenerative process. The wet and dry liver weight percentages were increased in intact rats fed acetylferrocene (0.15%) or diacetylferrocene (0.060%) but not with ferrocene (0.20%) or with the three injected by the sc route. Hepatic iron deposition was extensive in operated rats fed ferrocene and diacetylferrocene but was far lower in the intact animals on these diets or in the groups injected with the agents.
在部分肝切除的大鼠中，喂食添加了0.15%（重量）1,1'-二乙酰基二茂铁的基础日粮，肝脏再生程度在10天内有所增加，但与含有二茂铁（0.10%和0.30%）和乙酰基二茂铁（0.10%）的日粮相比，或在花生油溶液中皮下注射这些药剂时，与对照组的相应差异不显著。分别以750和100 ppm添加的托酚酮和秋水仙碱抑制了再生过程。喂食乙酰基二茂铁（0.15%）或二乙酰基二茂铁（0.060%）的完整大鼠肝脏湿重和干重百分比增加，但喂食二茂铁（0.20%）或通过皮下途径注射这三种药剂的大鼠肝脏湿重和干重百分比未增加。喂食二茂铁和二乙酰基二茂铁的手术大鼠肝脏铁沉积广泛，但在喂食这些日粮的完整动物或注射这些药剂的组中，肝脏铁沉积要低得多。
