Miloszewski K, Kelleher J, Walker B E, Davies T, Smith C L, Losowsky M S
Scand J Gastroenterol. 1975;10(5):481-5.
Urinary indican excretion was studied in 5 patients with steatorrhoea of pancreatic origin, 4 patients with steatorrhoea due to other causes, and 5 normal subjects. Treatment with pancreatic extract resulted in an immediate increase in indican excretion to above the normal range in patients with steatorrhoea due to pancreatic insufficiency. Administration of pancreatic extract did not result in a rise in the patients with steatorrhoea not due to pancreatic insufficiency, or in the normal subjects. In one patient with pancreatic insufficiency maintained on a low protein diet, the rise in indican excretion on replacement therapy was much slower and did not reach as high a level as in the patients on a normal protein diet. The possible mechanisms underlying these observations are discussed. It is suggested that the finding of a low indican excretion in the presence of steatorrhoea and its rise to above normal on pancreatic enzyme therapy is strongly suggestive of exocrine pancreatic insufficiency.
对5例胰腺源性脂肪泻患者、4例其他原因所致脂肪泻患者及5名正常受试者的尿中吲哚氰排泄情况进行了研究。对因胰腺功能不全导致脂肪泻的患者，给予胰腺提取物治疗后，吲哚氰排泄立即增加至正常范围以上。给予胰腺提取物对非胰腺功能不全导致脂肪泻的患者及正常受试者的吲哚氰排泄无升高作用。在1例维持低蛋白饮食的胰腺功能不全患者中，替代治疗时吲哚氰排泄的升高要慢得多，且未达到正常蛋白饮食患者那样高的水平。讨论了这些观察结果背后可能的机制。提示在脂肪泻存在时吲哚氰排泄降低，而在接受胰酶治疗时升高至正常范围以上，这一发现强烈提示胰腺外分泌功能不全。
