Nevalainen T J, Seppä A
Scand J Gastroenterol. 1975;10(5):521-7.
Closed duodenal loop was created in the rat by obstructing the duodenum on both sides of the common bile duct. Acute haemorrhagic pancreatitis developed in these animals within 24 hours. Increased serum amylase activity, pancreatic acinar cell necrosis, pancreatic oedema and haemorrhages, and intra-abdominal fat necroses, together with formation of ascites fluid containing high levels of amylase, were observed in the experimental animals. The findings support the view that reflux of the duodenal contents into the pancreatic duct is an important early pathogenetic mechanism in the development of acute pancreatitis. The closed-loop technique in the rat offers a simple and reliable experimental model for studies on acute pancreatitis.
通过在胆总管两侧阻塞十二指肠，在大鼠体内构建闭合十二指肠袢。这些动物在24小时内发生急性出血性胰腺炎。在实验动物中观察到血清淀粉酶活性升高、胰腺腺泡细胞坏死、胰腺水肿和出血，以及腹腔内脂肪坏死，同时形成含有高水平淀粉酶的腹水。这些发现支持十二指肠内容物反流至胰管是急性胰腺炎发生发展过程中一个重要的早期发病机制的观点。大鼠的闭合袢技术为急性胰腺炎的研究提供了一个简单可靠的实验模型。
