Noskov V B, Grigoriev A I
Institute of Biomedical Problems, Moscow, Russia.
Acta Astronaut. 1994 Dec;32(12):841-3. doi: 10.1016/0094-5765(94)90091-4.
In a number of flights, cosmonauts and astronauts have experienced aggravation of their health status and general condition in the initial hours and days in a weightless environment. One of the trigger mechanisms for the onset of these unfavourable conditions at the start of space flight is a redistribution of body fluids and a blood shift towards the head. To ensure controlled hypohydration as a countermeasure to the deleterious effects of 0-g and to investigate the feasibility to control adaptation, six cosmonauts were administered lasix once a day during the first 3 days of a mission. All data of the experiment (correction test, questionnaire, hematocrit) were recorded on a special form in the logbook and transmitted to the control centre for processing. Results showed that the diuretic weakened the sensation of discomfort and improved the cosmonauts' general condition. Objective indices of the correction test indicate an increased work ability of cosmonauts. After hypohydration, circulating plasma volumes in the group were reduced by 6.8 + 1.0% on average.
在多次飞行任务中，宇航员在失重环境的最初数小时和数天里，健康状况和总体状态出现了恶化。太空飞行开始时这些不利状况出现的触发机制之一是体液重新分布以及血液向头部转移。为确保进行可控性低水合作用以应对零重力的有害影响，并研究控制适应过程的可行性，在一次任务的前3天，每天给6名宇航员服用速尿。实验的所有数据（校正测试、问卷、血细胞比容）都记录在日志的特殊表格上，并传输到控制中心进行处理。结果表明，利尿剂减轻了不适感，改善了宇航员的总体状态。校正测试的客观指标表明宇航员的工作能力有所提高。低水合作用后，该组循环血浆量平均减少了6.8 + 1.0%。
