HL - A8：与甲状腺毒症的遗传联系。

HL-A8: a genetic link with thyrotoxicosis.

作者信息

Whittingham S, Morris P J, Martin F I

出版信息

Tissue Antigens. 1975 Jul;6(1):23-7. doi: 10.1111/j.1399-0039.1975.tb00607.x.

DOI:10.1111/j.1399-0039.1975.tb00607.x

Abstract

The incidence of HL-A8 was significantly increased in 64 Caucasian patients with thyrotoxicosis compared with 700 Australian blood donors (42% versus 24%). No significant correlation was observed between HL-A8 and autoantibodies to thyroid components in thyrotoxic patients; thus the association of HL-A8 must be either with the disease itself, or possibly with immune responses not tested for this study.

摘要

与700名澳大利亚献血者相比，64名患有甲状腺毒症的白种人患者中HL - A8的发生率显著增加（42%对24%）。在甲状腺毒症患者中，未观察到HL - A8与甲状腺成分自身抗体之间存在显著相关性；因此，HL - A8与疾病本身相关，或者可能与本研究未检测的免疫反应相关。