血小板信号传导中的整合素酪氨酸磷酸化
Integrin tyrosine phosphorylation in platelet signaling.
作者信息
Phillips D R, Prasad K S, Manganello J, Bao M, Nannizzi-Alaimo L
机构信息
COR Therapeutics, Inc., 256 East Grand Avenue, South San Francisco, California 94080, USA.
出版信息
Curr Opin Cell Biol. 2001 Oct;13(5):546-54. doi: 10.1016/s0955-0674(00)00250-7.
The beta 3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta 3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta-integrin cytoplasmic domain. Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals.
在血小板聚集过程中，αIIbβ3的β3整合素细胞质酪氨酸（ICY）基序发生酪氨酸磷酸化，导致Shc和肌球蛋白与β整合素细胞质结构域相互作用。缺乏β3 ICY基序酪氨酸的小鼠血小板形成有缺陷的聚集体且凝块回缩不良，这表明整合素酪氨酸磷酸化是β3整合素信号的关键介质。
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