Tanaka A, Adachi T, Takahashi T, Yamaha T
Toxicology. 1975 May;4(2):253-64. doi: 10.1016/0300-483x(75)90105-5.
Elimination, distribution and metabolism of di-(2-ethylhexyl)phthalate (DEHP) were studied in the rat by the tracer technique. About 80% of the dose was excreted in the urine and faeces in 5 to 7 days following intravenous or oral administration. Excretion in the urine was generally slightly greater than that in the faeces. After intravenous administration of [14C] DEHP the radioactivity was preferentially localized in the liver for a short period. Delayed excretion of DEHP was observed in particular in adipose tissue. After oral dosing no significant retention was found in organs and tissues. Radioactivity measurements showed that affinity was lowest for testicles and brain regardless of whether [14C] DEHP was administered orally or intravenously. Orally ingested DEHP was excreted unchanged in the faeces and four major metabolites were detected in the urine.
采用示踪技术在大鼠体内研究了邻苯二甲酸二（2-乙基己基）酯（DEHP）的消除、分布和代谢情况。静脉注射或口服给药后，约80%的剂量在5至7天内通过尿液和粪便排出。尿液中的排泄量通常略高于粪便中的排泄量。静脉注射[14C]DEHP后，放射性在短时间内优先定位在肝脏中。尤其在脂肪组织中观察到DEHP排泄延迟。口服给药后，在器官和组织中未发现明显的滞留现象。放射性测量表明，无论口服还是静脉注射[14C]DEHP，睾丸和大脑的亲和力最低。口服摄入的DEHP以原形从粪便中排出，在尿液中检测到四种主要代谢物。
