Teirlynck O A, Belpaire F
Arch Toxicol. 1985 Sep;57(4):226-30. doi: 10.1007/BF00324782.
The disposition of di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) was studied in the rat. Three hours after a single oral dose of DEHP (2.8 g/kg), plasma concentrations of 8.8 +/- 1.7 micrograms/ml DEHP and 63.2 +/- 8.7 micrograms/ml MEHP were reached. MEHP levels declined with a half-life of 5.2 +/- 0.5 h. The ratio of the area under the plasma concentration-time curve of MEHP to that of DEHP was 16.1 +/- 6.1. When 14C-DEHP was administered, 19.3 +/- 3.3% of the radioactivity was excreted in the urine within 72 h, the rest being excreted in the faeces. The urinary excretion rate of total radioactivity declined with a half-life of 7.9 +/- 0.5 h. Single administration of MEHP (0.4 g/kg) resulted in plasma concentrations of 84.1 +/- 14.9 micrograms/ml 3 h after dosing; the half-life of MEHP was 5.5 +/- 1.1 h. Multiple dosing with DEHP (2.8 g/kg/day) for 7 consecutive days produced no accumulation of DEHP or MEHP in plasma.
在大鼠体内研究了邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸单（2-乙基己基）酯（MEHP）的处置情况。单次口服DEHP（2.8 g/kg）3小时后，血浆中DEHP浓度达到8.8±1.7微克/毫升，MEHP浓度达到63.2±8.7微克/毫升。MEHP水平以5.2±0.5小时的半衰期下降。MEHP血浆浓度-时间曲线下面积与DEHP的比值为16.1±6.1。给予14C-DEHP后，72小时内19.3±3.3%的放射性通过尿液排出，其余通过粪便排出。总放射性的尿排泄率以7.9±0.5小时的半衰期下降。单次给予MEHP（0.4 g/kg）给药3小时后血浆浓度为84.1±14.9微克/毫升；MEHP的半衰期为5.5±1.1小时。连续7天多次给予DEHP（2.8 g/kg/天），血浆中DEHP或MEHP均未蓄积。
