Brown G D, Gordon S
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Nature. 2001 Sep 6;413(6851):36-7. doi: 10.1038/35092620.
The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans.
被称为β-1,3 - D -葡聚糖的碳水化合物聚合物对免疫系统有显著影响，例如通过与巨噬细胞和其他白细胞上的受体结合并激活它们来刺激抗肿瘤和抗菌活性。虽然已知β-葡聚糖能与诸如补体受体3（参考文献1）等受体结合，但有证据表明巨噬细胞上存在另一种β-葡聚糖受体。在此我们确定这种未知受体为dectin - 1（参考文献2），这一发现为β-葡聚糖的固有免疫识别提供了新的见解。
