Seredenin S B, Badyshtov B A, Neznamov G G, Makhnycheva A L, Kolotilinskaia N V, Nadorov S A
Laboratory of Pharmacogenetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Eksp Klin Farmakol. 2001 Jan-Feb;64(1):3-12.
The results of pharmacogenetic experiments revealed specificity of the emotional-stress reactions (ESR) in the inherited deterministic type of behavior and showed dependence of the benzodiazepine tranquilizer action on the ESR phenotype. Based on these data, we carried out experiments with a group of volunteers performing operator functions in a model of emotional-stress conditions. The results of these experiments allowed the operators to be divided into stress-resistant and stress-affected groups. The results of the data processing by methods of multidimensional statistics showed possibility of predicting the ESR phenotype and the qualitative effect of phenazepam (0.5 mg. p.o.) based on the individual topological and hormonal-biochemical characteristics of operators.
药物遗传学实验结果揭示了遗传性确定性行为类型中情绪应激反应（ESR）的特异性，并表明苯二氮䓬类镇静剂的作用依赖于ESR表型。基于这些数据，我们对一组在情绪应激条件模型中执行操作员功能的志愿者进行了实验。这些实验结果使操作员能够被分为抗应激组和应激影响组。通过多维统计方法对数据进行处理的结果表明，基于操作员的个体拓扑和激素生化特征，可以预测ESR表型和非那西泮（0.5毫克，口服）的定性效果。
