Seredenin S B, Badyshtov B A, Neznamov G G, Kolotilinskaia N V, Makhnycheva A L, Nadorov S A
Department of Pharmacogenetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Eksp Klin Farmakol. 2001 Mar-Apr;64(2):3-10.
Individual effects of the benzodiazepine tranquilizers phenazepam and gidazepam were studied in neurotic patients and in healthy volunteers tested for the operatory performance under emotiogenic conditions. It was found that manifestations of the tranquiliactivating, tranquilizing, and tranquilisedative effects depend on the individual sensitivity types of the patients and volunteers. The activating manifestations were most pronounced in hypostenic patients, while the sedative action was most significant in hyperstenic persons. The tranquilisedative effect of a single test dose of gidazepam (20 mg) allows predicting a low efficacy of the log-term therapy with benzodiazepines studied. In a group of 40 healthy volunteers, a single 20-mg dose of gidazepam increased the operatory under emotiogenic conditions performance in 19 persons and decreased the results in 12 cases. Volunteers in the first group were characterized as less stress-resistant with respect to a combination of psychological, psychophysiological, and hormonal-biochemical parameters as compared to the second group. It was concluded that the benzodiazepine test is worth of further elaborating as a means of predicting the stress resistance based on the effect of a model benzodiazepine tranquilizer under laboratory conditions.
在神经症患者以及在情绪激发条件下接受操作性能测试的健康志愿者中，研究了苯二氮䓬类镇静剂非那西泮和吉地西泮的个体效应。结果发现，安定激活、镇静和安定镇静作用的表现取决于患者和志愿者的个体敏感类型。激活表现在体质虚弱的患者中最为明显，而镇静作用在体质亢进的人身上最为显著。单次测试剂量的吉地西泮（20毫克）的安定镇静作用表明，所研究的苯二氮䓬类药物长期治疗的疗效可能较低。在一组40名健康志愿者中，单次服用20毫克吉地西泮后，19人的情绪激发条件下操作性能提高，12人的结果下降。与第二组相比，第一组志愿者在心理、心理生理和激素生化参数方面表现出抗压能力较弱。得出的结论是，苯二氮䓬类测试作为一种基于实验室条件下模型苯二氮䓬类镇静剂的作用来预测抗压能力的方法，值得进一步完善。
