Morozov I S, Barchukov V G, Riabichenko V V, Neznamov G G, Zhirnov E N
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 Sep-Oct;61(5):6-9.
In healthy volunteers a single dose (0.05 g) of hydazepam does not change, but in subjects with psychogenic stress-reactions one-week course of the drug (0.05 g/24 h) intensifies to optimum activation of the sympathoadrenal system in response to standard operator load, inducing prevalent excretion of norepinephrine but not of epinephrine in the urine and maintains a high level of dopamine and DOPA excretion. In operators working in a state of hypercapnia and hyperthermia a single dose of hydazepam (0.05 g) blocks stress activation of the sympathoadrenal system. In a state of hyperthermia hydazepam normalizes the blood histamine and serotonin content. In all cases hydazepam improves the condition of the operators and the quality of their work, which allows it to be considered an effective and safe agent for the correction of stress-induced disorders in operators.
在健康志愿者中，单剂量（0.05克）的海达西泮不会产生变化，但在患有心因性应激反应的受试者中，为期一周的该药物疗程（0.05克/24小时）会增强交感肾上腺系统对标准操作负荷的最佳激活，导致尿液中去甲肾上腺素而非肾上腺素的排泄普遍增加，并维持多巴胺和多巴的高排泄水平。在处于高碳酸血症和高热状态下工作的操作人员中，单剂量的海达西泮（0.05克）会阻断交感肾上腺系统的应激激活。在高热状态下，海达西泮可使血液中的组胺和血清素含量恢复正常。在所有情况下，海达西泮都能改善操作人员的状况及其工作质量，这使其被认为是一种有效且安全的药物，可用于纠正操作人员因压力引起的紊乱。
