Zhai Y, Saier M H
Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
J Mol Microbiol Biotechnol. 2001 Oct;3(4):501-2.
We designed a web-based program, WHAT, which uses a sliding window to determine and plot the hydropathy, amphipathicity, secondary structure and transmembrane topology along the length of any protein sequence. This method is based on programs designed by us for hydropathy and amphipathicity but on JNET and MEMSAT for secondary structure and transmembrane topology predictions, respectively. It has a user-friendly interface and a convenient input format. It is available at our website http://www.biology.ucsd.edu/~yzhai/biotools.html.
我们设计了一个基于网络的程序WHAT，它使用滑动窗口来确定并绘制任何蛋白质序列全长的亲水性、两亲性、二级结构和跨膜拓扑结构。该方法基于我们设计的用于亲水性和两亲性分析的程序，但二级结构和跨膜拓扑结构预测分别基于JNET和MEMSAT。它具有用户友好的界面和便捷的输入格式。可在我们的网站http://www.biology.ucsd.edu/~yzhai/biotools.html上获取。
