Riedel K, Kempf V A, Bechtold A, Klimmer M
Dept. of Medical Microbiology, Immunology and Hygiene, City Hospital Munich-Harlaching, Germany.
Infection. 2001 Aug;29(4):240-2. doi: 10.1007/s15010-001-1173-z.
A 17-year-old boy presented with a severe form of an acute disseminated encephalomyelitis (ADEM) with hemiparesis and coma after initial symptoms of a flu-like febrile infection 1 week previously. Titers against Mycoplasma pneumoniae were significantly increased in serum and cerebrospinal fluid (CSF). Detection of M. pneumoniae was achieved in the initial CSF sample using M. pneumoniae-specific PCR. The patient improved significantly on antimicrobial therapy with erythromycin and immunosupressive therapy with immunoglobulins and corticosteroids. This case report demonstrates a well-documented course of a central nervous system (CNS) infection resulting in the ADEM syndrome.
一名17岁男孩，在1周前出现类似流感的发热感染初始症状后，表现为严重形式的急性播散性脑脊髓炎（ADEM），伴有偏瘫和昏迷。血清和脑脊液（CSF）中抗肺炎支原体的滴度显著升高。使用肺炎支原体特异性PCR在初始脑脊液样本中检测到肺炎支原体。患者在接受红霉素抗菌治疗以及免疫球蛋白和皮质类固醇免疫抑制治疗后有显著改善。本病例报告展示了一例导致ADEM综合征的中枢神经系统（CNS）感染的详细病程。
