Sarkar S K, Arjun G, Saraswathy P, Ramamoorthy N
Radiopharmaceutical Programme, Board of Radiation and Isotope Technology, Navi Mumbai, India.
Appl Radiat Isot. 2001 Oct;55(4):561-7. doi: 10.1016/s0969-8043(00)00325-0.
99mTc eluate in 0.7/0.35 M acetic acid and in 1:1 v/v 0.7 M acetic acid: 0.025 M ammonium acetate (30-40 ml) was conveniently concentrated by passing through a small column of a readily available weak anion exchanger, DEAE cellulose, (200 mg, 6 x 8 mm) and subsequent elution with 3 ml normal saline, with greater than 90% recovery. The quality of pertechnetate thus obtained and its compatibility for preparing 99mTc compounds were satisfactory. This method was successfully applied to the alumina column chromatographic generator produced in-house and to a commercial 99Mo-99mTc generator after extensive clinical use. Potential for much higher concentration factors with compacted anion exchanger cartridges as well as applicability for 188W-188Re generator are discussed.
99mTc洗脱液（存在于0.7/0.35M乙酸中以及1:1体积比的0.7M乙酸:0.025M乙酸铵中，30 - 40ml）通过一小柱市售的弱阴离子交换剂DEAE纤维素（200mg，6×8mm）进行浓缩很方便，随后用3ml生理盐水洗脱，回收率大于90%。如此获得的高锝酸盐的质量及其用于制备99mTc化合物的兼容性令人满意。该方法在广泛的临床应用后成功应用于自制的氧化铝柱色谱发生器和商用99Mo - 99mTc发生器。文中还讨论了使用压实的阴离子交换剂柱筒实现更高浓缩系数的潜力以及该方法对188W - 188Re发生器的适用性。
