Mushtaq A
Isotope Production Division, Pakistan Institute of Nuclear Science & Technology, P.O. Nilore, Islamabad, Pakistan.
Nucl Med Commun. 2004 Sep;25(9):957-62. doi: 10.1097/00006231-200409000-00014.
This paper describes a simple and inexpensive post-elution anion exchange cartridge system for the concentration of 99mTcO4-/188ReO4-.
The system is based on generator elution with a mixture of 0.7 M acetic acid and 0.0225 M sodium chloride instead of physiological saline to provide high specific volume solutions of 99mTc and 188Re from 99Mo-99mTc and 188W-188Re generators, respectively. The passage of the bolus through an amine-type (Accell Plus QMA Sep-Pak) anion exchange cartridge results in trapping of the microscopic levels of the pertechnetate or perrhenate. Subsequent elution of the anion exchange cartridge with 2 ml of saline then provides high specific volume solutions of pertechnetate or perrhenate.
This new approach works effectively to obtain concentrated solutions of 99mTcO4- and 188ReO4- from commercially available alumina based Mo-Tc and W-Re generators, respectively.
