对从188W-188Re发生器获得的高铼酸盐（188Re）洗脱液进行两种浓缩方法的评估。

Evaluation of two methods for concentrating perrhenate (188 Re) eluates obtained from 188 W-188 Re generator.

作者信息

Sarkar Sishir Kumar, Venkatesh Meera, Ramamoorthy Natesan

机构信息

Board of Radiation and Isotope Technology (BRIT), BARC Vashi Complex, Navi Mumbai 400 705, India.

出版信息

Appl Radiat Isot. 2009 Feb;67(2):234-9. doi: 10.1016/j.apradiso.2008.09.011. Epub 2008 Oct 5.

DOI:10.1016/j.apradiso.2008.09.011

PMID:19056284

Abstract

Two novel and simple methods for post-elution concentration (PEC) of (188)Re-perrhenate, using (i) a single diethyl amino ethyl (DEAE) cellulose anion exchanger column and (ii) a combination of Dowex-1 x 8 and AgCl columns, are described here. In the first system, 20-25 ml of (188)Re-perrhenate in acidic ammonium acetate was trapped in the small anion exchanger column of DEAE cellulose which was subsequently recovered in 4 ml of normal saline. In the second method, (188)Re-perrhenate eluate in 20-40 ml normal saline was trapped on a small strong base anion exchanger column, Dowex-1 x 8, and recovered in 5 ml of 0.2M NaI solution and finally processed over 1g AgCl column so as to obtain it in physiological saline solution in a final volume of 6.5 ml including 1.5 ml de-ionized water washings. In both the methods, the radiochemical purity of (188)Re-perrhenate was >98% and (188)W breakthrough was less than 10(-3)%.

摘要

本文介绍了两种新颖且简便的用于高铼酸（¹⁸⁸）铼洗脱后浓缩（PEC）的方法，分别是：（i）使用单个二乙氨基乙基（DEAE）纤维素阴离子交换柱；（ii）结合使用Dowex - 1×8和AgCl柱。在第一种体系中，20 - 25 ml酸性醋酸铵中的高铼酸（¹⁸⁸）铼被捕获在DEAE纤维素的小型阴离子交换柱中，随后用4 ml生理盐水回收。在第二种方法中，20 - 40 ml生理盐水中的高铼酸（¹⁸⁸）铼洗脱液被捕获在小型强碱性阴离子交换柱Dowex - 1×8上，并用5 ml 0.2M NaI溶液回收，最后通过1g AgCl柱进行处理，以便在最终体积为6.5 ml的生理盐溶液中获得，其中包括1.5 ml去离子水洗涤液。在这两种方法中，高铼酸（¹⁸⁸）铼的放射化学纯度均>98%，钨（¹⁸⁸）W的突破小于10⁻³%。