Sarkar Sishir Kumar, Venkatesh Meera, Ramamoorthy Natesan
Board of Radiation and Isotope Technology (BRIT), BARC Vashi Complex, Navi Mumbai 400 705, India.
Appl Radiat Isot. 2009 Feb;67(2):234-9. doi: 10.1016/j.apradiso.2008.09.011. Epub 2008 Oct 5.
Two novel and simple methods for post-elution concentration (PEC) of (188)Re-perrhenate, using (i) a single diethyl amino ethyl (DEAE) cellulose anion exchanger column and (ii) a combination of Dowex-1 x 8 and AgCl columns, are described here. In the first system, 20-25 ml of (188)Re-perrhenate in acidic ammonium acetate was trapped in the small anion exchanger column of DEAE cellulose which was subsequently recovered in 4 ml of normal saline. In the second method, (188)Re-perrhenate eluate in 20-40 ml normal saline was trapped on a small strong base anion exchanger column, Dowex-1 x 8, and recovered in 5 ml of 0.2M NaI solution and finally processed over 1g AgCl column so as to obtain it in physiological saline solution in a final volume of 6.5 ml including 1.5 ml de-ionized water washings. In both the methods, the radiochemical purity of (188)Re-perrhenate was >98% and (188)W breakthrough was less than 10(-3)%.
本文介绍了两种新颖且简便的用于高铼酸（¹⁸⁸）铼洗脱后浓缩（PEC）的方法，分别是：（i）使用单个二乙氨基乙基（DEAE）纤维素阴离子交换柱；（ii）结合使用Dowex - 1×8和AgCl柱。在第一种体系中，20 - 25 ml酸性醋酸铵中的高铼酸（¹⁸⁸）铼被捕获在DEAE纤维素的小型阴离子交换柱中，随后用4 ml生理盐水回收。在第二种方法中，20 - 40 ml生理盐水中的高铼酸（¹⁸⁸）铼洗脱液被捕获在小型强碱性阴离子交换柱Dowex - 1×8上，并用5 ml 0.2M NaI溶液回收，最后通过1g AgCl柱进行处理，以便在最终体积为6.5 ml的生理盐溶液中获得，其中包括1.5 ml去离子水洗涤液。在这两种方法中，高铼酸（¹⁸⁸）铼的放射化学纯度均>98%，钨（¹⁸⁸）W的突破小于10⁻³%。
