Okamura S, Kameoka H, Miyazawa M
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan.
Nat Prod Lett. 2001;15(1):71-4. doi: 10.1080/10575630108041260.
The microbial transformation of 3,3,5-trimethylcyclohexanone was investigated using the plant pathogenic fungus, Glomerella cingulata. With this organism 3,3,5-trimethylcyclohexanone gave the corresponding cis- and trans-3,3,5-trimethylcyclohexanols with the ratio of 20:1 forming the cis-isomer highly stereoselectively, upon 5 days incubation together with 3,3,5-trimethyl-2-cyclohexen-1-one (isophrone) as a minor product.
利用植物病原真菌胶孢炭疽菌（Glomerella cingulata）对3,3,5-三甲基环己酮的微生物转化进行了研究。将该真菌与3,3,5-三甲基环己酮共同培养5天后，3,3,5-三甲基环己酮生成了相应的顺式和反式3,3,5-三甲基环己醇，二者比例为20:1，其中顺式异构体的生成具有高度立体选择性，同时还生成了少量产物3,3,5-三甲基-2-环己烯-1-酮（异佛尔酮）。
