竹红菌素B光致敏过程中产生的单线态氧（1O2）和自由基（O2.-、.OH、HB.-）的电子顺磁共振研究

EPR studies of singlet oxygen (1O2) and free radicals (O2.-, .OH, HB.-) generated during photosensitization of hypocrellin B.

作者信息

Zhiyi Z, Nenghui W, Qian W, Meifan L

机构信息

Institute of Biophysics, Academia Sinica, Beijing, China.

出版信息

Free Radic Biol Med. 1993 Jan;14(1):1-9. doi: 10.1016/0891-5849(93)90503-m.

DOI:10.1016/0891-5849(93)90503-m

PMID:8384147

Abstract

Hypocrellin B(HB), a peryloquinone derivative, is one of the main photosensitive agents, hypocrellin. This pigment, in combination with phototherapy, has been used in human medicine to cure various skin diseases. The photochemistry (Type I and II) of HB has been studied using spin-trapping and spin-counteraction techniques. The results show that the active oxygen (1O2, O2.-, .OH) mechanism of HB photosensitization can be converted into nonoxygen free radical (HB.-) mechanism completely when oxygen is exhausted in the experimental system. Under anaerobic conditions, HB only undergoes Type I reaction, generating nonoxygen free radical (HB.-).

摘要

竹红菌素B（HB）是一种苝醌衍生物，是主要的光敏剂竹红菌素之一。这种色素与光疗相结合，已被应用于人类医学中治疗各种皮肤病。利用自旋捕获和自旋对抗技术研究了HB的光化学（I型和II型）。结果表明，当实验体系中的氧气耗尽时，HB光敏化的活性氧（1O2、O2.-、.OH）机制可完全转化为非氧自由基（HB.-）机制。在厌氧条件下，HB仅发生I型反应，生成非氧自由基（HB.-）。