Brudastov Iu A, Sborets T S, Deriabin D G
Research Institute of Cellular and Intracellular Symbiosis, Orenburg.
Zh Mikrobiol Epidemiol Immunobiol. 2001 Mar-Apr(2):13-6.
The dynamics of the level of catalase and superoxidedismutase (SOD) expression by S. aureus isolated in persistent experimental kidney infection is described. A rise in the activity of the staphylococci under study during transition of the infectious process from the alteration to persistence stage. Changes in the expression of SOD and catalase were observed simultaneously with a decrease in hemolytic, fibrinolytic and protease activity, as well as in the presence of more pronounced clumping and an increase in the production of protein A, the antilysozyme and anticomplement activity of staphylococcal clones obtained from kidney tissue. The significance of all above-mentioned phenomena in the persistence of microorganisms is discussed.
描述了在持续性实验性肾脏感染中分离出的金黄色葡萄球菌过氧化氢酶和超氧化物歧化酶（SOD）表达水平的动态变化。在感染过程从病变阶段转变为持续阶段时，所研究的葡萄球菌活性升高。同时观察到SOD和过氧化氢酶表达的变化，以及溶血、纤维蛋白溶解和蛋白酶活性的降低，以及从肾脏组织获得的葡萄球菌克隆出现更明显的聚集、蛋白A产量增加、抗溶菌酶和抗补体活性增强。讨论了上述所有现象在微生物持续性中的意义。
