Talalaenko A N, Gordienko D V, Markova O P, Goncharenko N V, Pankrat'ev D V
Pharmacology Department, Donetsk State Medical University, pr. Il'icha 16, Donetsk, 340003 Ukraine.
Eksp Klin Farmakol. 2001 Mar-Apr;64(2):20-4.
The experiments using "illuminated site" and "threatening situation" avoidance tests on rats microinjected with GABA, glutamic acid, monoamines and their agonists and antagonists, as well as anxiosedative and anxioselective agents into the anterior hypothalamus revealed functional ambiguity in the neurochemical profile of this limbic brain formation in the anxiety states of various aversive genesis. Preliminary intraperitoneal injection of the monoamine and GABA antagonists, followed by the local administration of the antianxiety drugs studied, showed that the antiaversive action of chlordiazepoxide, fenibut, and indoter is manifested in both anxiety models via a GABAergic mechanism in the anterior hypothalamus. The anxiolytic effect of campiron is manifested only under negative-stressor zoosocial conditions and is mediated by the serotoninergic systems of this limbic brain formation.
在大鼠的前下丘脑显微注射γ-氨基丁酸（GABA）、谷氨酸、单胺及其激动剂和拮抗剂，以及抗焦虑和抗焦虑选择性药物后，使用“光照部位”和“威胁情境”回避试验进行的实验表明，在各种厌恶源引起的焦虑状态下，这个边缘脑区的神经化学特征存在功能上的模糊性。预先腹腔注射单胺和GABA拮抗剂，随后局部给予所研究的抗焦虑药物，结果显示，氯氮卓、芬布酯和吲哚酮的抗厌恶作用在两种焦虑模型中均通过前下丘脑的GABA能机制表现出来。坎皮隆的抗焦虑作用仅在负性应激的社会环境条件下表现出来，并且由这个边缘脑区的5-羟色胺能系统介导。
