Talalaenko A N, Krivobok G K, Babiĭ Iu V, Bogdanov V A, Perch N N
Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Nov-Dec;44(6):1116-23.
Chemical stimulation of the central nucleus of the amygdalar complex was carried out in rats during performance of tests of avoidance of "lighted square" and "threatening situation". Microinjections of monoamines, GABA, glutamate, some of their receptor agonists and antagonists revealed neurochemical heterogeneity of the structure and functional ambiguity of neurotransmitter systems in genesis of anxiety of different aversive modes. Chlordiazepoxid, phenibut, indoter, campiron, campironin decrease anxiety in the tests of avoidance of "lighted square" and "threatening situation", their effects being similar to those of dopamine, GABA, or serotonin. A conclusion is made that distinctions in spectra of anxiosedative and anxioselective drugs under study may be caused by unequal contribution of monoamine and amino acid transmitter mechanisms of the central region of the amygdalar complex in genesis of heteromodal aversive anxiety.
在大鼠进行“亮方块”回避和“威胁情境”测试期间，对杏仁核复合体中央核进行化学刺激。微量注射单胺、γ-氨基丁酸（GABA）、谷氨酸及其一些受体激动剂和拮抗剂，揭示了在不同厌恶模式焦虑发生过程中该结构的神经化学异质性以及神经递质系统的功能模糊性。氯氮卓、苯乙胺、吲哚酮、坎皮隆、坎皮隆宁在“亮方块”回避和“威胁情境”测试中可减轻焦虑，它们的作用与多巴胺、GABA或5-羟色胺相似。得出的结论是，所研究的抗焦虑和抗焦虑选择性药物谱的差异可能由杏仁核复合体中央区域单胺和氨基酸递质机制在异模态厌恶焦虑发生中的不同作用所致。
