Mikovskaia O I, Vetrilé L A, Trekova N A, Basharova L A, Evseev V A
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2001 Mar-Apr;51(2):190-6.
The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour.
