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Antibodies to dopamine as neuromodulators of behavioral responses of mice of different genotypes.

作者信息

Evseev V A, Mikovskaya O I, Vetrilé L A, Trekova N A, Basharova L A, Khlopushina T G, Gruden' M A

机构信息

Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.

出版信息

Neurosci Behav Physiol. 2003 Jun;33(5):507-12. doi: 10.1023/a:1023471402939.

DOI:10.1023/a:1023471402939
PMID:12921182
Abstract

The possibility of long-term changes in the innate characteristics of the behavior of mice of different genotypes (C57Bl/6 and BALB/c) after active immunization with dopamine-BSA conjugates was studied. These experiments revealed significant differences in the effects of anti-dopamine antibody on behavioral responses in an open field and neurotransmitter contents of brain structures in mice of different lines. Immunization with the dopamine-protein conjugate led to increases in the functional activity of the corresponding brain receptors, to different extents in mice of different lines.

摘要

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