Trekova N A, Khlopushina T G, Basharova L A, Vetrilé L A, Mikovskaia O I, Evseev V A
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Mar-Apr;48(2):251-9.
Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT.
