Solution-phase synthesis of an aminomethyl-substituted biaryl library via sequential amine N-alkylation and Suzuki cross-coupling.
作者信息
Organ M G, Arvanitis E A, Dixon C E, Lavorato D J
机构信息
Department of Chemistry, York University, 4700 Keele Street, Toronto M3J 1P3, Ontario, Canada.
出版信息
J Comb Chem. 2001 Sep-Oct;3(5):473-6. doi: 10.1021/cc010018l.
PMID:11549366
Abstract
Described herein is the semiautomated preparation of a 20-member aminomethyl-substituted biaryl library. The two-step solution-phase synthesis was achieved via sequential N-alkylation of various amines with either 3- or 4-bromobenzyl bromide and Suzuki cross-coupling of the resultant aryl bromides with various boronic acids.
摘要
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