邻二取代芳基碘化物的羰基化交叉偶联反应：位阻芳基酮的便捷合成
Carbonylative cross-coupling of ortho-disubstituted aryl iodides. convenient synthesis of sterically hindered aryl ketones.
作者信息
O'Keefe B Michael, Simmons Nicholas, Martin Stephen F
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
出版信息
Org Lett. 2008 Nov 20;10(22):5301-4. doi: 10.1021/ol802202j. Epub 2008 Oct 24.
Abstract
A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho-disubstituted aryl iodides is reported. Carbonylative Suzuki-Miyaura couplings of a variety of aryl boronic acids provide an array of substituted biaryl ketones in modest to excellent yield. A carbonylative Negishi coupling that utilizes alkynyl nucleophiles is also described.
摘要
报道了一种温和且通用的用于空间位阻邻二取代芳基碘化物羰基化交叉偶联的方法。多种芳基硼酸的羰基化铃木-宫浦偶联反应以中等至优异的产率提供了一系列取代的联芳基酮。还描述了一种利用炔基亲核试剂的羰基化根岸偶联反应。
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