Aguila A, Herrera A G, Morrison D, Cosgrove B, Perojo A, Montesinos I, Pérez J, Sierra G, Gemmell C G, Brock J H
Group for Research on Lactoferrin, Iron Metabolism and Immunomodulation, Finlay Institute, Havana, Cuba.
FEMS Immunol Med Microbiol. 2001 Aug;31(2):145-52. doi: 10.1111/j.1574-695X.2001.tb00511.x.
The in vitro antistaphylococcal activity of lactoferrin and the antibiotic resistance of clinical Staphylococcus aureus isolates obtained from three different sites of infection were examined. Antibiotic, but not lactoferrin resistance correlated with selective antibiotic pressure, and nosocomial and most community isolates were antibiotic resistant, whereas only a third of each group was resistant to lactoferrin. The antimicrobial activity of lactoferrin, both in defined medium and in normal human plasma serum, was dependent upon its ferrochelating properties. Therapeutic approaches based on the use of ferrochelating agents such as lactoferrin combined with antimicrobial drugs may help to counteract the reduced efficacy of current antibiotics.
研究了乳铁蛋白的体外抗葡萄球菌活性以及从三个不同感染部位分离得到的临床金黄色葡萄球菌菌株的抗生素耐药性。抗生素耐药性（而非乳铁蛋白耐药性）与选择性抗生素压力相关，医院获得性菌株和大多数社区菌株具有抗生素耐药性，而每组中只有三分之一对乳铁蛋白耐药。乳铁蛋白在限定培养基和正常人血浆血清中的抗菌活性取决于其铁螯合特性。基于使用铁螯合剂（如乳铁蛋白）联合抗菌药物的治疗方法可能有助于对抗当前抗生素疗效降低（的问题）。
