[Quantitative evaluation of neurovegetative systemic changes based on the degree of minute-rhythmic coupling and control quality in acute and chronic diazépam therapy of neuroses].

In 10 patients with definite forms of neurosis, controlphysiologic and biorhythmometric investigations were carried out to establish the effectiveness of diazepam therapy. After acute application of 10 mg diazepam, an increase in the degree of minute-rhythmic coupling correlated positively with a decrease of the control area, of the time adjustment of the heart rate after load-related deflection, and with an increase in a derived complex parameter of control quality. Chronic therapy with diazepam reversed the positive tendency of the biorhythmometric and control parameters. The results permit the conclusion that the minute-rhythmic coupling degree lends itself to diagnostic evaluation of the actual synchronization state or the related neurovegetative reaction state.