Dabelsteen E, Roed-Petersen B, Pindbrog J J
Acta Pathol Microbiol Scand A. 1975 May;83(3):292-300. doi: 10.1111/j.1699-0463.1975.tb01876.x.
Tissue from 40 oral premalignant lesions were investigated for the presence of blood group antigens A and B. The material included 18 leukoplakias, 1 erythroplakia, and 3 lichen planus, all with varying degrees of epithelial dysplasia, and 18 leukoplakias without histological evidence of impending malignancy. Thirty-eight benign keratotic oral muscosal lesions were included as a control group. The antigens were demonstrated by a double layer immunofluorescence technique, and the reactivity was compared, by titration, to the reactivity of adjacent normal epithelium from the same patient. All 22 lesions with dysplsia showed decreased reactivity for blood group antigen. Among the 18 leukoplakias without any signs of impending malignancy 4 cases demonstrated loss of antigen reactivity. None of 38 benign control lesions showed any change in antigen reactivity as compared to normal adjacent epithelium.
对40例口腔癌前病变组织进行血型抗原A和B的检测。材料包括18例白斑、1例红斑和3例扁平苔藓，均伴有不同程度的上皮发育异常，以及18例无组织学证据提示即将发生恶变的白斑。38例良性角化性口腔黏膜病变作为对照组。采用双层免疫荧光技术检测抗原，并通过滴定法将反应性与同一患者相邻正常上皮的反应性进行比较。所有22例发育异常病变的血型抗原反应性均降低。在18例无任何即将恶变迹象的白斑中，4例显示抗原反应性丧失。与相邻正常上皮相比，38例良性对照病变均未显示抗原反应性有任何变化。
